Production of Egg Yolk Antibodies Specific to House Dust Mite Proteins

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Production of Egg Yolk Antibodies Specific to House Dust Mite Proteins

PURPOSE House dust mites (HDMs) are an important source of indoor allergens associated with asthma, rhinitis and atopic dermatitis. Chicken immunoglobulin (Ig) Y is known to be a good alternative to mice and rabbit antibody production. In this study, we produced IgYs specific to HDMs and investigated their IgE immunoreactivities. MATERIALS AND METHODS Total IgYs were isolated from the yolks o...

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Specific Chicken Egg Yolk Antibodies against Enterotoxigenic Escherichia coli K99 in Serum and Egg Yolk of Immunized Laying Hens

Enterotoxigenic Escherichia coli K99 is one of the dominant pathogens associated with diarrhea of calves. Immunoglobulin Y (IgY), has been used as an inexpensive alternative to antibiotics for the prevention and therapy of several bacterial infections. The study aimed to prepare IgY antibodies against E. coli K99 and to investigate its in vitro effectiveness. E. c...

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Mimotope identification using phage displayed random peptide libraries against monoclonal antibodies specific to house dust mite.

Random heptapeptide T7 and random 12mer M13 phage libraries were employed to identify mimotopes binding to monoclonal antibodies (MAb) specific to house dust mite. After selection of bound phage by bio-panning and determination of binding specificity, DNA of selected bound phages was amplified, sequenced and aligned for peptide similarity. Eight mimotopes which were partially matched with Der f...

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House dust mite allergy

The importance of the allergens in sensitisation and disease can be readily demonstrated in regions with and without mite infestation. Dose-responce relationships in regions with high infestation are less easy to detect pointing to the importance of variations of other factors. The relationship between allergic disease and IgE antibody shows that only people with very high responses become pers...

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Specific IgE, IgG and IgG4 antibodies against house dust mite in patients with bronchial asthma.

Serum levels of total IgE, specific IgE, IgG and IgG4 against house dust mite were measured in mite-sensitive asthma patients receiving immunotherapy with house dust. Serum levels of total IgE, mite specific IgE and IgG did not significantly change during the course of hyposensitization. Increased levels of mite specific IgG4 were observed in patients during immunotherapy. The increase in speci...

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ژورنال

عنوان ژورنال: Yonsei Medical Journal

سال: 2014

ISSN: 0513-5796,1976-2437

DOI: 10.3349/ymj.2014.55.4.999